Biomarkers for Lupus Nephritis: A Critical Appraisal
نویسندگان
چکیده
منابع مشابه
Biomarkers for Lupus Nephritis: A Critical Appraisal
Kidney disease is one of the most serious manifestations of systemic lupus erythematosus (SLE). Despite the improvement in the medical care of SLE in the past two decades, the prognosis of lupus nephritis remains unsatisfactory. Besides exploring more effective but less toxic treatment modalities that will further improve the remission rate, early detection and treatment of renal activity may s...
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Current treatment of severe lupus nephritis is unsatisfactory in terms of both outcome and toxicity. To improve the efficacy and decrease the adverse effects of immunosuppression, it would be ideal to be able to predict the course and pathology of lupus nephritis and adjust therapy appropriately. This will require biomarkers that reflect disease activity. Recently, significant effort has been p...
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Renal biopsy remains the standard of care for the evaluation of suspected flares in lupus nephritis (1) and is generally indicated when proteinuria, active urine sediment, or elevated serum creatinine is present. By the time that a patient presents with these features, injury induced by the lupus disease activity may already be present, including acute and more concerning, chronic changes. Rena...
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Lupus nephritis is characterized by intrarenal inflammation. Leukocytes trafficking from peripheral blood into affected tissues spaces represent an important factor in the development of many renal diseases. During the past few years has been attributed the crucial role of a family of chemotactic cytokines--the chemokines--in this process. In the course of renal diseases, the infiltration of mo...
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ژورنال
عنوان ژورنال: Journal of Biomedicine and Biotechnology
سال: 2010
ISSN: 1110-7243,1110-7251
DOI: 10.1155/2010/638413